Difference between revisions of "Pyrophosphate phosphohydrolase"

Revision as of 12:33, 13 May 2014

Pyrophosphate phosphohydrolase that catalyze the reaction that converts Pyrophosphate into two molecules of Phosphate.

Failed to parse (Cannot store math image on filesystem.): PP \rightarrow 2 P

Simple Michaelis-Menten rate law is used for this reaction ^[1]

\frac{V_{max[PP]}}{[PP] + K_{m}^{PP}}

A mean body weight is defined as 75Kg in Konig et. al ^[1]. The $V_{max}$ is calculated by multiplying the reported value with body weight.

Parameter	Value	Units	Organism	Remarks
$V_{max}$	$0.36$	$mM/min^{-1}$	Human Liver
Failed to parse (Cannot store math image on filesystem.): K_{m}^{PP}	$0.96$	mM	Human cancer

The maximum and minimum value for Failed to parse (Cannot store math image on filesystem.): K_{m}^{PP} has been reported to be 0.25 and 1.67. Calculating the mean and Std. Dev. using the range formula gives a value of $0.96 \pm 0.35$ for this parameter.

Parameter	Value	Units	Organism	Remarks
$V_{max}$	$0.36$	$mM/min^{-1}$	Human Liver
Failed to parse (Cannot store math image on filesystem.): K_{m}^{PP}	$0.96 \pm 0.35$	mM	Rat liver

↑ ^1.0 ^1.1 M. König, S. Bulik, H.G. Holzhütter (2012), Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism, PLoS Comput. Biol., 8 (6), p. e1002577

@@ Line 36: / Line 36: @@
 ==Parameters with uncertainty==
-* The value of <math>V_{max}</math> is reported to be <math>9.6 %</math> of <math>V_{max, PGLM}</math>. The Std. Dev. for <math>V_{max, PGLM}</math> was considered to be <math>10.5%</math> of its mean value. Same error percentage is considered for <math>V_{max}</math>.
+* The maximum and minimum value for <math>K_{m}^{PP}</math> has been reported to be 0.25 and 1.67. Calculating the mean and Std. Dev. using the range formula gives a value of <math>0.96 \pm 0.35</math> for this parameter.
 {|class="wikitable"
@@ Line 52: / Line 52: @@
 |-
 |<math>K_{m}^{PP}</math>
-|<math> 0.0054 </math>
+|<math>0.96 \pm 0.35</math>
 |mM
 |Rat liver
 |
 |}
 ==References==
 <references/>