Difference between revisions of "Pyrophosphate phosphohydrolase"

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'''Pyrophosphate phosphohydrolase''' that catalyze the reaction that converts Pyrophosphate into two molecules of Phosphate.
 
'''Pyrophosphate phosphohydrolase''' that catalyze the reaction that converts Pyrophosphate into two molecules of Phosphate.
  

Revision as of 11:57, 13 May 2014


Pyrophosphate phosphohydrolase that catalyze the reaction that converts Pyrophosphate into two molecules of Phosphate.

Chemical equation

Failed to parse (Cannot store math image on filesystem.): PP \rightarrow 2 P

Rate equation

Simple Michaelis-Menten rate law is used for this reaction [1]

\frac{V_{max[PP]}}{[PP] + K_{m}^{PP}}


Parameter values

  • A mean body weight is defined as 75Kg in Konig et. al [1]. The V_{max} is calculated by multiplying the reported value with body weight.
Parameter Value Units Organism Remarks
V_{max} 131.25 min^{-1} Human Liver
Failed to parse (Cannot store math image on filesystem.): K_{m}^{PP} Failed to parse (Cannot store math image on filesystem.): 0.0054 mM Rat liver

Parameters with uncertainty

  • The value of V_{max} is reported to be 9.6 % of V_{max, PGLM}. The Std. Dev. for V_{max, PGLM} was considered to be 10.5% of its mean value. Same error percentage is considered for V_{max}.
Parameter Value Units Organism Remarks
V_{max} 131.25 min^{-1} Human Liver
Failed to parse (Cannot store math image on filesystem.): K_{m}^{PP} Failed to parse (Cannot store math image on filesystem.): 0.0054 mM Rat liver


References

  1. 1.0 1.1 M. König, S. Bulik, H.G. Holzhütter (2012), Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism, PLoS Comput. Biol., 8 (6), p. e1002577