Difference between revisions of "Prostaglandin Transporter"
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|Transfected Human embryonic kidney cells (HEK293) | |Transfected Human embryonic kidney cells (HEK293) | ||
|Substrate: PGE3 | |Substrate: PGE3 | ||
| − | <ref name="Gose2016"> [https://www.ncbi.nlm.nih.gov/pubmed/26692285 Gose T. ''Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.'' Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. doi: 10.1016/j.prostaglandins.2015.12.003. Epub 2015 Dec 10.]</ref> | + | |<ref name="Gose2016"> [https://www.ncbi.nlm.nih.gov/pubmed/26692285 Gose T. ''Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.'' Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. doi: 10.1016/j.prostaglandins.2015.12.003. Epub 2015 Dec 10.]</ref> |
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| + | |0.000376 ± 3.4e-5 | ||
| + | |mM | ||
| + | |PGT-expressing Madin-Darby Canine Kidney Epithelial Cells (MDCK) cells | ||
| + | |Substrate: PGH2 | ||
| + | |<ref name="Chi2010"> [http://www.sciencedirect.com/science/article/pii/S0006291X10005723 Chi Y. ''The prostaglandin transporter PGT transports PGH2'' Biochemical and Biophysical Research Communications, Volume 395, Issue 2, 30 April 2010, Pages 168–172]</ref> | ||
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! Reference | ! Reference | ||
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| − | + | |(Extensive googling can't find values - will use ABC and CIF of 10) | |
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Revision as of 14:33, 22 May 2017
Contents
Reaction
Chemical equation
Rate equation
Parameters
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 0.0054 | mM | Human Eye | Substrate: Latanoprost, a prostaglandin F2a analogue | [1] |
| 0.000331 ± 0.000131 | mM | Transfected Human embryonic kidney cells (HEK293) | Substrate: PGE2 | |
| 0.007202 ± 0.000595 | mM | Transfected Human embryonic kidney cells (HEK293) | Substrate: PGE3 | [2] |
| 0.000376 ± 3.4e-5 | mM | PGT-expressing Madin-Darby Canine Kidney Epithelial Cells (MDCK) cells | Substrate: PGH2 | [3] |
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| (Extensive googling can't find values - will use ABC and CIF of 10) |
| Value | Units | Species | Notes | Reference |
|---|---|---|---|---|
| 125 | ppm | Human | Vector:Lung
Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C |
[4] |
| 17.4 | ppm | Human | Expression Vector: Esophagus
Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C |
[5] |
| 2.82 | ppm | Human | Vector:Gut
Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C |
[4] |
References
- ↑ M. Kraft The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. doi: 10.1167/iovs.09-4290. Epub 2009 Dec 17.
- ↑ 2.0 2.1 Gose T. Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. doi: 10.1016/j.prostaglandins.2015.12.003. Epub 2015 Dec 10.
- ↑ Chi Y. The prostaglandin transporter PGT transports PGH2 Biochemical and Biophysical Research Communications, Volume 395, Issue 2, 30 April 2010, Pages 168–172
- ↑ 4.0 4.1 M. Kim A draft map of the human proteome Nature, 2014 509, 575–581
- ↑ M. Wilhelm Mass-spectrometry-based draft of the human proteome Nature, 2014 509, 582–587
