Difference between revisions of "Notes"
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* Two types of simulation is being run. In one type of simulation for Control and for all types of silencing new parameter distribution is generated each time. In the next type of simulation first a parameter distribution is created and with that same parameter distribution the ensemble models of control and PYK silencing is being generated. | * Two types of simulation is being run. In one type of simulation for Control and for all types of silencing new parameter distribution is generated each time. In the next type of simulation first a parameter distribution is created and with that same parameter distribution the ensemble models of control and PYK silencing is being generated. | ||
| + | * When we silence the model using our sekeleton model, the PEP accumulates and PYR depletes. But when we considered the parameter distribution for other parameters it behaves differently. | ||
* When we silence the Pyruvate Kinase (dividing Vmax of PYK with 2 or 4) the PEP is supposed to accumulate and PYR is supposed to deplete. In our model PYR does deplete but PEP does not accumulate. The rate laws has been verified and no mistake was found there. Therefore now the impact of other parameters on this silencing activity is being adjusted. | * When we silence the Pyruvate Kinase (dividing Vmax of PYK with 2 or 4) the PEP is supposed to accumulate and PYR is supposed to deplete. In our model PYR does deplete but PEP does not accumulate. The rate laws has been verified and no mistake was found there. Therefore now the impact of other parameters on this silencing activity is being adjusted. | ||
Revision as of 09:57, 4 August 2014
- Two types of simulation is being run. In one type of simulation for Control and for all types of silencing new parameter distribution is generated each time. In the next type of simulation first a parameter distribution is created and with that same parameter distribution the ensemble models of control and PYK silencing is being generated.
- When we silence the model using our sekeleton model, the PEP accumulates and PYR depletes. But when we considered the parameter distribution for other parameters it behaves differently.
- When we silence the Pyruvate Kinase (dividing Vmax of PYK with 2 or 4) the PEP is supposed to accumulate and PYR is supposed to deplete. In our model PYR does deplete but PEP does not accumulate. The rate laws has been verified and no mistake was found there. Therefore now the impact of other parameters on this silencing activity is being adjusted.
