Mevalonate pathway with limonene synthesis

The mevalonate (MVA) pathway is one of two independent pathways that is responsible to produce isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) -- the two main precursors to produce terpenes. This pathway has seven enzymes to produce IPP and DMAPP, and these compounds are consumed to form geranyl diphosphate (GPP) -- the precursor for the synthesis of monoterpenes such as limonene.

Mevalonate pathway models

We have two MVA pathway models. Both models describe the synthesis of limonene, but one is more detailed than the other. In the basic MVA model, the enzyme concentrations are set as fixed concentrations whereas in the improved MVA model, the enzyme concentrations are not fixed and its degradation is taken into account. A detailed description of these models along with the simulations and analysis that were carried out can be accessed by clicking on the buttons below.