Degradation of r

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The mRNA of ScbR (r) degrades.

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Chemical equation

r\rightarrow \varnothing

Rate equation

 r= d_{mR}\cdot[r]

Parameters

The parameter of this reaction is the degradation rate of r (d_{mR}).

Name Value Units Origin Remarks
d_{mR} 0.045-0.4 [1] [2] min^{-1} Half life of mRNA in Gram positive bacteria (low GC content)

Half life of mRNA in Actinomycetes

Parameters with uncertainty

The most plausible parameter value for the d_{mR} is decided to be  0.1785 min^{-1} and the confidence interval  1.55 . This means that the mode of the PDF is 0.1785 and the range where 95% of the values are found is between 0.115525 and 0.277259 min^{-1}.

The probability distributionfor the parameter, adjusted accordingly in order to reflect the above values, is the following:

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The location and scale parameters of the distribution are:

Parameter μ σ
d_{mR} -1.6753 0.2187

References

  1. Kristoffersen SM, Haase C, Weil MR, et al. Global mRNA decay analysis at single nucleotide resolution reveals segmental and positional degradation patterns in a Gram-positive bacterium. Genome Biology. 2012;13(4):R30.
  2. Ortiz-Ortiz, L. and Bojalil, L.F. and Yakoleff, V. Biological, Biochemical, and Biomedical Aspects of Actinomycetes. Elsevier, 2013