Difference between revisions of "Degradation of r"
(→Parameters) |
(→Parameters with uncertainty) |
||
Line 34: | Line 34: | ||
==Parameters with uncertainty== | ==Parameters with uncertainty== | ||
+ | The most plausible parameter value for the <math>d_{mR}</math> is decided to be <math> 0.1785 min^{-1} </math> and the confidence interval <math> 1.55 </math>. This means that the mode of the PDF is 0.1785 and the range where 95% of the values are found is between 0.115525 and 0.277259 <math>min^{-1}</math>. | ||
+ | |||
+ | The probability distributionfor the parameter, adjusted accordingly in order to reflect the above values, is the following: | ||
+ | |||
+ | [[Image:DmR.png|500px]] | ||
+ | |||
+ | The location and scale parameters of the distribution are: | ||
+ | {|class="wikitable" | ||
+ | ! Parameter | ||
+ | ! μ | ||
+ | ! σ | ||
+ | |- | ||
+ | |<math>d_{mR}</math> | ||
+ | |<math>-1.6753</math> | ||
+ | |<math>0.2187</math> | ||
+ | |} | ||
==References== | ==References== | ||
<references/> | <references/> |
Revision as of 20:57, 28 September 2015
The mRNA of ScbR (r) degrades.
Contents
Chemical equation
Rate equation
Parameters
The parameter of this reaction is the degradation rate of r ().
Name | Value | Units | Origin | Remarks |
---|---|---|---|---|
[1] [2] | Half life of mRNA in Gram positive bacteria (low GC content)
Half life of mRNA in Actinomycetes |
Parameters with uncertainty
The most plausible parameter value for the is decided to be and the confidence interval . This means that the mode of the PDF is 0.1785 and the range where 95% of the values are found is between 0.115525 and 0.277259 .
The probability distributionfor the parameter, adjusted accordingly in order to reflect the above values, is the following:
The location and scale parameters of the distribution are:
Parameter | μ | σ |
---|---|---|
References
- ↑ Kristoffersen SM, Haase C, Weil MR, et al. Global mRNA decay analysis at single nucleotide resolution reveals segmental and positional degradation patterns in a Gram-positive bacterium. Genome Biology. 2012;13(4):R30.
- ↑ Ortiz-Ortiz, L. and Bojalil, L.F. and Yakoleff, V. Biological, Biochemical, and Biomedical Aspects of Actinomycetes. Elsevier, 2013