Difference between revisions of "Degradation of R2"

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== Rate equation ==
 
== Rate equation ==
  
<center><math> r= d_{R}\cdot[R_{2}]</math></center>
+
<center><math> r= d_{R_{2}}\cdot[R_{2}]</math></center>
  
 
== Parameters ==
 
== Parameters ==
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! Remarks
 
! Remarks
 
|-
 
|-
|<math>d_{R}</math>
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|<math>d_{R_{2}}</math>
 
|<math>0.000833-0.001667</math> <ref name="Trötschel2013"> Trötschel C, Albaum SP, Poetsch A. ''Proteome turnover in bacteria: current status for Corynebacterium glutamicum and related bacteria.'' Microbial biotechnology. 2013;6(6):708-719.</ref>  
 
|<math>0.000833-0.001667</math> <ref name="Trötschel2013"> Trötschel C, Albaum SP, Poetsch A. ''Proteome turnover in bacteria: current status for Corynebacterium glutamicum and related bacteria.'' Microbial biotechnology. 2013;6(6):708-719.</ref>  
 
| <math>min^{-1}</math>
 
| <math>min^{-1}</math>
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! σ
 
! σ
 
|-
 
|-
|<math>d_{R}</math>
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|<math>d_{R_{2}}</math>
 
|<math>-6.7120</math>
 
|<math>-6.7120</math>
 
|<math>0.174</math>
 
|<math>0.174</math>

Revision as of 03:21, 2 October 2015

The ScbR homo-dimer (R2) degrades.

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Chemical equation

R_{2}\rightarrow \varnothing

Rate equation

 r= d_{R_{2}}\cdot[R_{2}]

Parameters

The parameter of this reaction is the degradation rate of R2 (d_{R}).

Name Value Units Origin Remarks
d_{R_{2}} 0.000833-0.001667 [1] min^{-1} Degradation rates of proteins in S. coelicolor

based on radioactive decay

Parameters with uncertainty

The most plausible parameter value for the d_{R} is decided to be  0.00118 min^{-1} and the confidence interval  1.41 . This means that the mode of the PDF is 0.00118 and the range where 95% of the values are found is between 0.8369\cdot 10^{-3} and 1.67 \cdot 10^{-3}min^{-1}.

The probability distribution for the parameter, adjusted accordingly in order to reflect the above values, is the following:

DR.png

The location and scale parameters of the distribution are:

Parameter μ σ
d_{R_{2}} -6.7120 0.174

References

  1. Trötschel C, Albaum SP, Poetsch A. Proteome turnover in bacteria: current status for Corynebacterium glutamicum and related bacteria. Microbial biotechnology. 2013;6(6):708-719.