Difference between revisions of "Degradation Pathways"
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+ | Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected. | ||
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|+ style="text-align: left;" | Degradation Pathways | |+ style="text-align: left;" | Degradation Pathways |
Revision as of 11:52, 5 September 2016
Upon being transported out of the cell, the eicosanoids accumulate in the interstitial fluid, which for simplicity is referred to as the extracellular compartment in the model. A decay constant was included for each extracellular metabolite to represent degradation. To describe the breaking down of metabolites an irreversible mass action rate law was used for reactions 43-64. The half life of each eicosanoid was initially assumed as 24 hours, but will be made metabolite specific when all of the values have been collected.
Reaction # | Species | Half Life | Rate constant | Notes | Reference |
---|---|---|---|---|---|
44 | exPGF2a | ||||
45 | exTXB2 | 20 - 30 minutes | Quoted in a textbook(https://books.google.co.uk/books?id=_9kEeTjyJdMC&pg=PA864&lpg=PA864&dq=half+life+txa2&source=bl&ots=2OTF4Mh2Jk&sig=hu79GprliUcW4QE_Zm79islesOA&hl=en&sa=X&ved=0ahUKEwj0oo2sgfjOAhXLIcAKHcaPDHQQ6AEIRjAI#v=onepage&q=half%20life%20txa2&f=false) with no ref. | ||
46 | exTXA2 | 20 - 30 seconds | Quoted in a textbook(https://books.google.co.uk/books?id=_9kEeTjyJdMC&pg=PA864&lpg=PA864&dq=half+life+txa2&source=bl&ots=2OTF4Mh2Jk&sig=hu79GprliUcW4QE_Zm79islesOA&hl=en&sa=X&ved=0ahUKEwj0oo2sgfjOAhXLIcAKHcaPDHQQ6AEIRjAI#v=onepage&q=half%20life%20txa2&f=false) with no ref. | ||
47 | ex6-KETO-PGF2A | ||||
48 | exPGI2 | ||||
49 | exPGE2 | ||||
50 | ex15-DEOXY-PGJ2 | ||||
51 | exPGJ2 | ||||
52 | exPGD2 | ||||
53 | exPGH2 | ||||
54 | ex5-OXO-ETE | ||||
55 | ex5-HETE | ||||
56 | exLTB4 | ||||
57 | exLTC4 | ||||
58 | exLTA4 | ||||
59 | ex5-HPETE | ||||
60 | ex15-HETE | ||||
61 | ex15-HPETE | ||||
62 | ex12-HETE | ||||
63 | ex12-HPETE | ||||
64 | exAA | ||||
(-30) | kcal/mol | Unspecified | Calculations with a Gaussian98 suite of programs
Enzyme: COX (Unspecific) Substrate: Arachidonate Temperature: 298.15 K Pressure: 1 bar |
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