Difference between revisions of "CMK"
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CMK is modelled reversible using random bi-bi generic Michaelis-Menten equation <ref>Hanekom</ref> | CMK is modelled reversible using random bi-bi generic Michaelis-Menten equation <ref>Hanekom</ref> | ||
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:<math> | :<math> | ||
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| [CDPME] || CDPME concentration || μM | | [CDPME] || CDPME concentration || μM | ||
|- | |- | ||
− | | [ | + | | [ATP] || ATP concentration || μM |
|- | |- | ||
− | | [ | + | | [CDPME2P]|| CDPME2P concentration || μM |
+ | |- | ||
+ | | [ADP] || ADP concentration || μM | ||
|} | |} | ||
+ | |||
+ | == References == | ||
+ | <references /> |
Revision as of 22:12, 7 March 2017
The reaction
4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase (CMK) catalyses the production of CDP-ME2P from CDP-ME. This ATP-dependent reaction is the fourth step in the non-mevalonate or methylerythritol-phosphate (MEP) pathway.
Equation Rate
CMK is modelled reversible using random bi-bi generic Michaelis-Menten equation [1]
where :
Parameter | Description | Units |
---|---|---|
VCMK | Reaction rate for CMK | μM/min |
Kcatforward | Forward turnover number | min-1 |
KmCDPME | Michaelis-Menten constant for CDPME | μM |
KmATP | Michaelis-Menten constant for ATP | μM |
KmCDPME2P | Michaelis-Menten constant for CDPME2P | μM |
KmADP | Michaelis-Menten constant for ADP | μM |
Keq | Equilibrium constant | unitless |
[CDPME] | CDPME concentration | μM |
[ATP] | ATP concentration | μM |
[CDPME2P] | CDPME2P concentration | μM |
[ADP] | ADP concentration | μM |
References
- ↑ Hanekom