Difference between revisions of "CMK"
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4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase (CMK) catalyses the production of CDP-ME2P from CDP-ME. This ATP-dependent reaction is the fourth step in the non-mevalonate or methylerythritol-phosphate (MEP) pathway. | 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase (CMK) catalyses the production of CDP-ME2P from CDP-ME. This ATP-dependent reaction is the fourth step in the non-mevalonate or methylerythritol-phosphate (MEP) pathway. | ||
+ | :<math> | ||
+ | |||
+ | CDPME + ATP \rightleftharpoons CDPME2P + ADP | ||
+ | |||
+ | </math> | ||
== Equation Rate == | == Equation Rate == |
Revision as of 18:21, 7 March 2017
The reaction
4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase (CMK) catalyses the production of CDP-ME2P from CDP-ME. This ATP-dependent reaction is the fourth step in the non-mevalonate or methylerythritol-phosphate (MEP) pathway.
Equation Rate
The reversible Michaelis-Menten equation to model the dynamic changes of CMK is:
where :
Parameter | Description | Units |
---|---|---|
VCMK | Reaction rate for CMK | μM/min |
Kcatforward | Forward turnover number | min-1 |
KmCDPME | Michaelis-Menten constant for CDPME | μM |
KmATP | Michaelis-Menten constant for ATP | μM |
KmCDPME2P | Michaelis-Menten constant for CDPME2P | μM |
KmADP | Michaelis-Menten constant for ADP | μM |
Keq | Equilibrium constant | unitless |
[CDPME] | CDPME concentration | μM |
[Limonene] | Limonene concentration | μM |
[PP] | PP concentration | μM |