Acetoacetyl transferase (AACT)

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Acetoacetyl transferase (AACT, EC 2.3.1.9 ) is the first step in the MVA pathway. In the model, AACT is local to E. coli.



2 AcetylCoA  \rightleftharpoons AcetoacetylCoA + coA


AACT Parameter Values

Keq values for AACT
Value ΔG°' (kcal/mol) Literature Reference
1 ± 0.5 E-02 Keq value for AACT [1]
6.63E-06 7.06 Keq value for AACT [2]
1.1 ± 0.2 E-05 6.8 Keq value for AACT [3]

AACT Parameter Distribution Properties

References

  1. Lan, E. I. and J. C. Liao (2012). "ATP drives direct photosynthetic production of 1-butanol in cyanobacteria." PNAS 109(16): 6018-6023.
  2. MetaCyc
  3. Gilbert, H. F., et al. (1981). "The relation of acyl transfer to the overall reaction of thiolase I from porcine heart." The Journal of Biological Chemistry