Prostaglandin Transporter

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Revision as of 16:35, 22 May 2017 by Muttley93 (talk | contribs) (Parameters)
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Reaction

Chemical equation

 Intracellular Lipid  \rightleftharpoons Extracellular Lipid

Rate equation

Parameters

Michaelis-Menten Constants
Value Units Species Notes Reference
0.0054 mM Human Eye Vector: HEK-OATP2A1 or HEK-OATP2B1 and the respective vector controls

Substrate: Latanoprost, a prostaglandin F2a analogue pH: 7.5 Temp: 37 °C

[1]
0.000331 ± 0.000131 mM Transfected Human embryonic kidney cells (HEK293) Substrate: PGE2

pH: unknown Temp: 37 °C

[2]
0.007202 ± 0.000595 mM Transfected Human embryonic kidney cells (HEK293) Substrate: PGE3

pH: unknown Temp: 37 °C

[2]
0.000376 ± 3.4e-5 mM PGT-expressing Madin-Darby Canine Kidney Epithelial Cells (MDCK) cells Substrate: PGH2

pH: unknown Temp: unknown

[3]
Turnover Number
Value Units Species Notes Reference
(Extensive googling can't find values - will use ABC and CIF of 10)
Abundance
Value Units Species Notes Reference
125 ppm Human Vector:Lung

Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C

[4]
17.4 ppm Human Expression Vector: Esophagus

Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C

[5]
2.82 ppm Human Vector:Gut

Enzyme: SLCO2A1 pH: 7.5 Temperature: 37 °C

[4]

References

Related Reactions