Monocarboxylate (Lactate) transporter
Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.
Chemical equation
![Lactate_{in} \rightleftharpoons Lactate_{out}](/wiki/images/math/9/4/7/9473e479aa23c3e2aa5b6b08d60ad0d7.png)
Rate equation
Reversible Michaelis-Menten rate law is used
![\frac{V_{f}\frac{[Lactate_{in}]}{Km_{Lactate_{in}}}- V_{r}\frac{[Lactate_{out}]}{Km_{Lactate_{out}}}}{1+ \frac{[Lactate_{in}]}{Km_{Lactate_{in}}} + \frac{[Lactate_{out}]}{Km_{Lactate_{out}}} }](/wiki/images/math/5/9/d/59d3468d02be251532c898a93215b6a9.png)
Parameter values
Parameter | Value | Organism | Remarks |
---|---|---|---|
![]() |
2.5 [2] | ||
![]() |
|||
![]() |
4.5 | ||
![]() |
4.54 |
References
- ↑ Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)
- ↑ Manning Fox JE et. al. (2000). Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529(Pt2):285-293