Fructose 1,6 bisphosphate aldolase
This enzyme splits fructose 1, 6-bisphosphate into two sugars that are isomers of each other. These two sugars are Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate (Gly3P).
Contents
Chemical equation
![Fru1,6BP \rightleftharpoons Gly3P + DHAP](/wiki/images/math/8/1/0/8109d3b19111514e7b52001dd5ea1219.png)
Rate equation
Reversible Uni-Bi Michaelis-Menten is used. [1]
![\frac{V_{mf} \frac{[Fru1,6BP]}{K_{Fru1,6BP}} - V_{mr}\frac{[DHAP][G3P]}{K_{DHAP}K_{Gly3P}} }{1 + \frac{[Fru1,6BP]}{K_{Fru1,6BP}} + \frac{[DHAP]}{K_{DHAP}} +\frac{[Gly3P]}{K_{Gly3P}} + \frac{[DHAP][Gly3P]}{K_{DHAP}K_{Gly3P}} }](/wiki/images/math/d/f/0/df0be717a9e6f06e44e264eacb312fd7.png)
Parameters
Parameter | Value | Organism | Remarks |
---|---|---|---|
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0.2 [2] | Hela cell line | |
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0.18[2] | Rodent AS-30D hepatoma | |
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0.009[2] | Hela cell line | |
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0.16[2] | Rodent AS-30D hepatoma | |
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0.08[2] | Rodent AS-30D hepatoma |
Alternative parameter values
References
- ↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)
- ↑ 2.0 2.1 2.2 2.3 2.4 Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)