Enzyme Parameters

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Table of enzyme parameters with their respective confidence interval, location and scale parameter. The value for each enzyme parameter is the weighted mode, calculated using literature parameters and the parameter alogirthm described by Breitling, Hawari and Tsigkinopoulou. The algorithm was also used in order to calculate the confidence interval for each data set, the larger the confidence interval, the larger the descrepancy between literature values. The location and scale parameters stated for each parameter describe the log normal distributions which were generated using a two-by-two system of the equations containing the cumulative distribution function (CDF) and the mode. For more detail about these calculations please visit the Quantification of parameter uncertainty.

Quantifying Parameter Uncertainty
Enzyme	Parameter	Weighted Mode	Confidence Interval	Location Parameter	Scale Parameter
12-LOX	Km	0.00755	5.83	-4.36	0.727
	Kcat	252	1.38	5.56	0.159
15-LOX	Km	0.00780	1.78	-4.78	0.278
	Kcat	66.6	5.30	4.68	0.700
5-LOX	Km	0.00855	4.19	-4.38	0.617
	Kcat	1460	1.50	7.29	0.0244
COX-2	Km	0.00368	3.38	-5.32	0.540
	Kcat	1640	1.50	7.44	0.199
cPLA2	Km	0.0113	4.21	-4.11	0.618
	Kcat	2650	2.63	8.08	0.443
LTA4H	Km	0.00230	5.28	-5.59	0.695
	Kcat	20.4	3.87	3.36	0.589
LTC4S	Km	0.03	6.75	-2.91	0.773
	Kcat	1440	1.50	7.29	0.145
PGDS	Km	0.0040	10.0	-4.78	0.891
	Kcat	158	10.0	5.86	0.891
PGES	Km	0.162	1.50	-1.81	0.0825
	Kcat	2820	1.50	7.95	0.0610
PGFS	Km	0.00340	6.90	-5.08	0.780
	Kcat	14.9	10.0	3.50	0.891
PGIS	Km	0.0126	1.50	-4.36	0.123
	Kcat	125	1.50	4.85	0.159
PHGPx	Km	5.56	19.3	2.86	1.07
	Kcat	1280	6.31	10.0	0.752
TXAS	Km	0.00700	2.45	-4.79	0.415
	Kcat	1630	1.50	7.40	0.0740