Glucose Transporter

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Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Glucose is a vital source of energy for all life.

Chemical equation

Glucose_{out} \rightleftharpoons Glucose_{in}

Rate equation

Mono-Substrate reversible Michaelis-Menten with Haldane substitution is used[1].

v = \frac{V_{mf}\Big([Glucose_{out}] - \frac{[Glucose_{in}]}{K_{eq}}\Big)}{K_{Glucose_{out}}\Big(1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}}\Big) + [Glucose_{out}}]

Parameters

Parameter Value Organism Remarks
V_{mf} 0.017 [2] HeLa cell line Vm in U × (mg total cellular protein) at 37^{\circ}C
K_{eq} 1[3]
K_{Glucose_{in}} 9.3[2]
K_{Glucose_{out}} 10[3]


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Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
  2. 2.0 2.1 Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, et. al.(2009). Kinetics of transport and phosphorylation of glucose in cancer cells. Journal of Cell. Physiology, 221 , pp. 552–559 (doi)
  3. 3.0 3.1 Arbitrary value