Geranyl diphosphate synthase: Detailed information on the kinetic values obtained from the literature

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Detailed description of the values used for the GPPS model

Parameter Value Units Description References
KmDMAPP 390 µM An excerpt from Schmidt, et. al. 2010 [1]
KmDMAPP 58 µM An excerpt from Mann, et. al. 2011 [2]
KmIPP 163 µM An excerpt from Mann, et. al. 2011 [2]
Kcat 0.7 min-1 An excerpt from Mann, et. al. 2011 [2]
Kcat 5.1 min-1 An excerpt from Mann, et. al. 2011 [2]
KmDMAPP 11.60 µM with Co2+ as a cofactor, and IPP as a co-substrate

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
KmIPP 0.84 µM with Co2+ as a cofactor, and DMAPP as co-substrate

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
KmDMAPP 1103 µM with Mg2+ as a cofactor, and IPP as co-substrate

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
KmIPP 11.79 µM with Mg2+ as a cofactor, and DMAPP as co-substrate

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
[IPP] 15 µM with Co2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
[DMAPP] 50 µM with Co2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
Vmaxforward 0.44 µmol min-1mg-1 with Co2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
Vmaxforward 0.67 µmol min-1mg-1 with Co2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
Vmaxforward 2.39 µmol min-1mg-1 with Mg2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
Vmaxforward 0.17 µmol min-1mg-1 with Mg2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
[IPP] 50 µM with Mg2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]
[DMAPP] 50 µM with Mg2+ as a cofactor

An excerpt from Frick et al, 2013, Table 1, page 4198

[3]

Reference

  1. ↑ Schmidt, A. 2010. "A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies", Plant Physiology, 152:639-655
  2. ↑ 2.0 2.1 2.2 2.3 Mann, F.M. 2011. "Rv0989c encodes a novel (E)-geranyl diphosphate synthase facilitating decaprenyl diphosphate biosynthesis in Mycobacterium tuberculosis", FEBS Letters, 585(3):549-554 Cite error: Invalid <ref> tag; name "Mann2011" defined multiple times with different content Cite error: Invalid <ref> tag; name "Mann2011" defined multiple times with different content Cite error: Invalid <ref> tag; name "Mann2011" defined multiple times with different content
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Frick, S. 2013. "Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway", PNAS, 110(11):4194-4199
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