Glucose Transporter

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Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Glucose is a vital source of energy for all life.

Chemical equation

Glucose_{out} \rightleftharpoons Glucose_{in}

Rate equation

Mono-Substrate reversible Michaelis-Menten with Haldane substitution is used[1].

v = \frac{V_{mf}\Big([Glucose_{out}] - \frac{[Glucose_{in}]}{K_{eq}}\Big)}{K_{Glucose_{out}}\Big(1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}}\Big) + [Glucose_{out}}]

Parameters

Parameter Value Organism Remarks
V_{mf} 0.055 [2] Human Tumor Cell Vm in U × (mg total cellular protein)
K_{eq} 1
Failed to parse (syntax error): K_{Glucose_{in} 10
Failed to parse (syntax error): |<math>K_{Glucose_{out} 9.3
Total 15.00

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
  2. Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, et. al.(2009). Kinetics of transport and phosphorylation of glucose in cancer cells. Journal of Cell. Physiology, 221 , pp. 552–559 (doi)