Glucose Transporter

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Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Glucose is a vital source of energy for all life.

Chemical equation

Glucose_{out} \rightleftharpoons Glucose_{in}

Rate equation

Mono-Substrate reversible Michaelis-Menten with Haldane substitution is used[1].

v = \frac{V_{mf}\Big([Glucose_{out}] - \frac{[Glucose_{in}]}{K_{eq}}\Big)}{K_{Glucose_{out}}\Big(1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}}\Big) + [Glucose_{out}}]

Parameters

Parameter Value Organism Remark
V_{mf} 0.055 [2] Human Tumor Cell
Bread 4 3.00
Butter 1 5.00
Total 15.00

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
  2. Marín-Hernández A, Rodríguez-Enríquez S, Vital-González P A et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J, Vol. 273 , pp. 1975–1988