Phosphoglycerate dehydrogenase
The enzyme Phosphoglycerate dehydrogenase (PDH) catalyzes the reaction to convert 3-phospho-D-glycerate (P3G) to phosphonooxypyruvate (PHP). The cofactors NADH and NAD+ are not considered in this reaction.
Chemical equation
![P3G \rightleftharpoons PHP](/wiki/images/math/d/5/5/d55dbbe57345953df42092a4b196e25c.png)
Rate equation
Modified rate equation is used [1]
![\frac{ serA*K_{cat}A.\frac{[3PG]}{Ka_{3PG}}}{\frac{1 + \frac{[3PG]}{Ka_{3PG}} + \frac{[PHP]}{Ka_{PHP}} }{1+ \frac{[SER]}{KiA_{SER}}}}](/wiki/images/math/e/1/8/e1804c036835cc92c33f583f6c5c526d.png)
Parameters
References
- ↑ Smallbone K, Stanford NJ (2013) Kinetic modeling of metabolic pathways: Application to serine biosynthesis. In: Systems Metabolic Engineering, Humana Press. pp. 113–121