Phosphoglucomutase

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Phosphoglucomutase (PGLM) facilitates the interconversion of glucose 1-phosphate and glucose 6-phosphate by transfering a phosphate group on an α-D-glucose monomer from the 1' to the 6' position in the forward direction or the 6' to the 1' position in the reverse direction.

Chemical reaction

Glc6P \rightleftharpoons Glc1P

Rate equation

Mono substrate reversible Michelis-Menten with Haldane substitution is used as a rate law. [1]

 \frac{\frac{V_{max}}{K_{Glc6P}}\left( [Glc6P] - \frac{[Glc1P]}{K_{eq}} \right) }{1 + \frac{[Glc6P]}{K_{Glc6P}} + \frac{[Glc1P]}{K_{Glc1P}} }

Parameter values

References

  1. Palm, D.C. (2013). The regulatory design of glycogen metabolism in mammalian skeletal muscle (Ph.D.). University of Stellenbosch