Monocarboxylate (Lactate) transporter

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Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.

Chemical equation

 Lactate_{in} \rightleftharpoons Lactate_{out}

Rate equation

Reversible Michaelis-Menten rate law is used

 \frac{V_{f}\frac{[Lactate_{in}]}{Km_{Lactate_{in}}}- V_{r}\frac{[Lactate_{out}]}{Km_{Lactate_{out}}}}{1+ \frac{[Lactate_{in}]}{Km_{Lactate_{in}}} - \frac{[Lactate_{out}]}{Km_{Lactate_{out}}} }

References

  1. Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)