Fructose 1,6 bisphosphate aldolase

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This enzyme splits fructose 1, 6-bisphosphate into two sugars that are isomers of each other. These two sugars are Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate (Gly3P).

Chemical equation

 Fru1,6BP \rightleftharpoons Gly3P + DHAP

Rate equation

Reversible Uni-Bi Michaelis-Menten is used. [1]

\frac{V_{mf} \frac{[FBP]}{K_{FBP}} - V_{mr}\frac{[DHAP][G3P]}{K_{DHAP}K_{Gly3P}} }{1 + \frac{[FBP]}{K_{FBP}} + \frac{[DHAP]}{K_{DHAP}} +\frac{[Gly3P]}{K_{Gly3P}} + \frac{[DHAP][Gly3P]}{K_{DHAP}K_{Gly3P}} }

Parameters

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)