Triosephosphate isomerase

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This enzyme rapidly inter-converts the molecules Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate (Gly3P). Gly3P is removed as soon as it is formed to be used in the next step of glycolysis.

Chemical equation

 DHAP \rightleftharpoons  Gly3P

Rate equation

Reversible Michaelis-Menten is used [1]

 v = \frac{ V_{mf}\frac{[DHAP]}{K_{DHAP}} - V_{mr}\frac{[Gly3P]}{K_{Gly3P}}  }{1 + \frac{[DHAP]}{K_{DHAP}} + \frac{[Gly3P]}{K_{Gly3P}} }

Paramters

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)