Triosephosphate isomerase

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This enzyme rapidly inter-converts the molecules dihydroxyacetone phosphate and glyceraldehyde phosphate. Glyceraldehyde phosphate is removed as soon as it is formed to be used in the next step of glycolysis.

Chemical equation

 DHAP \rightleftharpoons  Gly3P

Rate equation

Reversible Michaelis-Menten is used [1]

 v = \frac{ V_{mf}\frac{[DHAP]}{K_{DHAP}} - V_{mr}\frac{[Gly3P]}{K_{Gly3P}}  }{1 + \frac{[DHAP]}{K_{DHAP}} + \frac{[Gly3P]}{K_{Gly3P}} }

Paramters

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)