Phosphoserine phosphatase

This enzyme converts PSER to Serine.

Reaction equation

PSER \rightleftharpoons Serine

Special rate law is used. ^[1]

\frac{serB*KcatB* \frac{[PSER]}{Kb_{PSER}} }{ 1 + \frac{[PSER]}{Kb_{PSER}} + \frac{[Serine]}{Kb_{Serine}} }

Parameter	Value	Units	Organism
$serB$	0.25 ^[2]	mM	Escherichia coli
$KcatB$	1.43 ^[2]	1/s
$KB_{PSER}$	0.0015^[2]	mM
$KB_{Serine}$	0.15^[2]	mM

The value of $KB_{PSER}$ is reported as $0.036 \pm 0.0008$ for human brain in ^[3].

Two values of $KcatB$ for Porphyromonas gingivalis (nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium) are reported in Tribble et. al.^[4]; 1.508, 2.94. The value with uncertainty comes as $2.22 \pm 1.01$ .

Parameter	Value	Units	Organism
$serB$	0.25	mM	Escherichia coli
$KcatB$	$2.22 \pm 1.01$	1/s	Porphyromonas gingivalis
$KB_{PSER}$	$0.036 \pm 0.0008$ ^[3]	mM	Human brain
$KB_{Serine}$		mM	Escherichia coli

↑ Smallbone K, Stanford NJ (2013). Kinetic modeling of metabolic pathways: Application to serine biosynthesis. In: Systems Metabolic Engineering, Humana Press. pp. 113–121
↑ ^2.0 ^2.1 ^2.2 ^2.3 Turnaev II, Ibragimova SS, Usuda Y et al (2006). Mathematical modeling of serine and glycine synthesis regulation in Escherichia coli. Proceedings of the fifth international conference on bioinformatics of genome regulation and structure 2:78–83 Cite error: Invalid <ref> tag; name "Turnaev_2006" defined multiple times with different content
↑ ^3.0 ^3.1 Shetty, V.; Shetty, K.T. (1990), Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs, Neurochem. Res. 16, 1203-1210
↑ Tribble, G.D.; Mao, S.; James, C.E.; Lamont, R.J. (2006), A Porphyromonas gingivalis haloacid dehalogenase family phosphatase interacts with human phosphoproteins and is important for invasion, Proc. Natl. Acad. Sci. USA 103, 11027-11032 (2006)