Monocarboxylate (Lactate) transporter
Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.
Contents
Chemical equation
![Lactate_{in} \rightleftharpoons Lactate_{out}](/wiki/images/math/9/4/7/9473e479aa23c3e2aa5b6b08d60ad0d7.png)
Rate equation
Reversible Michaelis-Menten rate law is used
Parameter values
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
![]() |
2.5 [2] | ![]() |
Human tumor cells | |
![]() |
2.4 [3] | ![]() |
Rat liver cells | |
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4.5 [3] | mM | Rat liver cell | |
![]() |
4.54 [2] | mM | Human tumor cells |
Parameters with uncertainty
- Among different isoforms the MCT1 in Tumour cells are considered in this model. The
is defined as Failed to parse (Cannot store math image on filesystem.): 4.38 \pm 0.74 and Failed to parse (Cannot store math image on filesystem.): V_{mf} = 2.5 \pm 0.2 [2].
- In the legend of Table-1 of Cite error: Invalid
<ref>
tag;
refs with no name must have content it states Km and Vmax values for monocarboxylate transport into mouse Ehrlich Lettre ́ tumor cells were taken in to consideration. Therefore we consider these values to be for and
. Here the values are given in
with 7 experiments. Calculating Std. Dev. from S.E gives,
for
and Failed to parse (Cannot store math image on filesystem.): 20.7 \pm 3.44
for
.
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
![]() |
Failed to parse (Cannot store math image on filesystem.): 2.5 \pm 0.2 | ![]() |
Human tumor cells | |
![]() |
Failed to parse (Cannot store math image on filesystem.): 20.7 \pm 3.44 | ![]() |
Human Tumor cell | |
![]() |
Failed to parse (Cannot store math image on filesystem.): 4.38 \pm 1.74 (6) | mM | Human tumour cell | |
![]() |
![]() |
mM | Human tumor cells |
References
- ↑ Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)
- ↑ 2.0 2.1 2.2 Manning Fox JE et. al. (2000). Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529(Pt2):285-293
- ↑ 3.0 3.1 Jackson VN, Halestrap AP (1996) The kinetics, substrate, and inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2’,7’-bis(carboxyethyl)-5(6)-carboxyfluorescein. J Biol Chem 271:861–868