3-phosphoglycerate kinase
3-Phosphoglycerate kinase (PGK) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP. Like all kinases it is a transferase.
Contents
Chemical equation
Rate equation
Random Bi-Bi reversible Michaelis-Menten euation for non-interacting substrates are used. [1]
Parameter values
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
8.7 [2] | HeLa cell line | |||
2.5[1] | ||||
0.079[1] | mM | |||
0.13[1] | mM | |||
0.04[1] | mM | |||
0.27[1] | mM |
Parameters with uncertainty
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
Failed to parse (Cannot store math image on filesystem.): 2630 \pm 2630 ± 420 [3] | HeLa cell line | |||
Failed to parse (Cannot store math image on filesystem.): 833 \pm 50 [3] | ||||
[3] | mM | |||
[3] | mM | |||
[3] | mM | |||
[3] | mM |
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)
- ↑ Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Szabo, J.; Varga, A.; Flachner, B.; Konarev, P.V.; Svergun, D.I.; Zavodszky, P.; Vas, M. (2008), Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase, FEBS Lett. 582, 1335-1340