Metabolite concentrations
Initial Concentration
Initial concentration of the metabolites are listed below
Metabolites | Initial concentrations |
---|---|
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5 mM (Fixed) [1] |
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ATP | 8.70 mM [2] |
Glc-6-P | 1.3 mM [2] |
ADP | 2.7 mM [2] |
Fru-6-P | 0.5 mM [2] |
Fru-1,6-BP | 0.38 mM [2] |
DHAP | 0.93 mM [2] |
Gly3P | 0.9 mM [2] |
NAD | 1.3 mM [2] |
1,3BPG | ![]() |
NADH | ![]() |
3PG | ![]() |
2PG | ![]() |
PEP | 0.32 mM [2] |
Pyruvate | 8.5 mM [2] |
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33 mM [2] (Fixed) |
Glycogen | 135 mM [2] (Fixed) |
Pi | 4 mM [2] (Fixed) |
AMP | 0.4 mM [2] |
6PG | 0.39 mM [2] (Fixed) |
Xy5P | ![]() |
Ery4P | ![]() |
CIT | 1.7 [2] (Fixed) |
F-2,6-BP | ![]() |
Glc-1-P | ![]() |
UTP | 0.13 [5] |
PPi | ![]() |
UDPG | ![]() |
Glycogen | 112 [4] |
PHP | 0.60 [8] |
PSER | 0.09 [8] |
Serine | 4.90 [8] |
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4.90 (fixed) [8] |
References
- ↑ Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
- ↑ 3.0 3.1 Reitzer L J (1980). The pentose cycle. J. Biol. Chem., 255 , pp. 5616–5626
- ↑ 4.0 4.1 Lambeth MJ & Kushmerick MJ (2002). A computational model for glycogenolysis in skeletal muscle. Ann Biomed Eng 30, 808–827
- ↑ Keppler D, Rudiger J & Decker K (1970) Enzymatic determination of uracil nucleotides in tissues. Anal Biochem 38, 105–114.
- ↑ Palm, D.C. (2013). The regulatory design of glycogen metabolism in mammalian skeletal muscle (Ph.D.). University of Stellenbosch
- ↑ Albe KR, Butler MH & Wright BE (1990). Cellular concentrations of enzymes and their substrates. J Theor Biol 143, 163–195.
- ↑ 8.0 8.1 8.2 8.3 Smallbone K, Stanford NJ (2013). Kinetic modeling of metabolic pathways: Application to serine biosynthesis. In: Systems Metabolic Engineering, Humana Press. pp. 113–121