Glycogen synthase
Glycogen synthase (GS) converts glucose to glycogen. It takes short polymers of glucose and converts them into long polymers one by one into a polymeric chain for storage as glycogen.
Chemical equation
![UDPG + Glucose \rightarrow UDP + Glycogen](/wiki/images/math/9/5/2/9528664742251b0bd5adf1183c00f789.png)
Rate equation
MWC model (Monod-Wyman-Changeux model) is used to model the reaction mechanism of this enzyme.[1]. Glc6P activates GS by binding to an allosteric site of this enzyme.
![\frac{K_{cat,r}[GS]n\frac{[UDPG]}{K_{UDPG}} \left( 1 + \frac{[UDPG]}{K_{UDPG}} + \frac{[ATP]}{K'_{r,ATP}} \right)^{n-1}}{\left( 1 + \frac{[UDPG]}{K_{UDPG}} + \frac{[ATP]}{K'_{t,ATP}} \right)^n L_{0} \left( \frac{1 + \frac{[Glc6P]}{K_{t,Glc6P}} + \frac{[ATP]}{K_{t,ATP}} }{1 + \frac{[Glc6P]}{K_{r,Glc6P}} + \frac{[ATP]}{K_{r,ATP}} } \right)^n + \left( 1 + \frac{[UDPG]}{K_{UDPG}} + \frac{[ATP]}{K'_{r,ATP}} \right)^n }](/wiki/images/math/2/2/0/220346954816c1ecb263e36a83fee3f7.png)
Parameter values
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
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4 [1] | Dimensionless | Rabbit muscle | |
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1004 [1] | ![]() |
Rabbit muscle | |
Total[GS] | ![]() |
mM | ||
L | 0.25 [1] | Dimensionless | ||
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0.72[1] | mM | Rat muscle | |
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mM | Rat muscle | |
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0.29[1] | mM | Rat muscle | |
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4.94[1] | mM | Rat muscle | |
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2.33[1] | mM | Rat muscle | |
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15.92[1] | mM | Rat muscle | |
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3.93[1] | mM | Rat muscle |