Phosphoserine amino-transferase

This enzyme catalyzes reaction to convert Phosphohydroxypyruvate (PHP) to phosphoserine (PSER).

Chemical equation

PHP \rightleftharpoons PSER

Special rate equation ^[1] is used.

\frac{serC * KcatC * \frac{[PHP]}{Kc_{PHP}} }{ 1 + \frac{[PHP]}{Kc_{PHP}} + \frac{[PSER]}{Kc_{PSER}} }

Parameter	Value	Units	Organism
$serC$	0.1 ^[2]	mM	Escherichia coli
$KcatC$	1.75 ^[3]	1/s
$Kc_{PHP}$	0.0015^[3]	mM
$Kc_{PSER}$	0.0017^[3]	mM

↑ Smallbone K, Stanford NJ (2013). Kinetic modeling of metabolic pathways: Application to serine biosynthesis. In: Systems Metabolic Engineering, Humana Press. pp. 113–121
↑ Turnaev II, Ibragimova SS, Usuda Y et al (2006). Mathematical modeling of serine and glycine synthesis regulation in Escherichia coli. Proceedings of the fifth international conference on bioinformatics of genome regulation and structure 2:78–83
↑ ^3.0 ^3.1 ^3.2 Drewke C, Klein M, Clade D et al (1996) 4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis. FEBS Lett 390:179–182