Transformation of PGI2 to 6-K-PGF1α

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Due to ring strain, PGI2 is rapidly hydrolysed to 6-keto-PGF1a. This is a non-enzymatic reaction and results in the formation of a hydroxyl group at C9 and a ketone at C6, by incorporating two hydrogens and one oxygen.

Reaction

Chemical equation

$PGI2 \rightleftharpoons 6-K-PGF1α$

Rate equation

Parameters

• See transformation of TXA2 to TXB2

Related Reactions

• Transformation of PGH2 to PGI2