Difference between revisions of "Phosphoglycerate dehydrogenase"
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==Rate equation== | ==Rate equation== | ||
Modified rate equation is used <ref name = "Smallbone_2013">Smallbone K, Stanford NJ (2013). ''Kinetic modeling of metabolic pathways: Application to serine biosynthesis''. In: Systems Metabolic Engineering, Humana Press. pp. 113–121</ref> | Modified rate equation is used <ref name = "Smallbone_2013">Smallbone K, Stanford NJ (2013). ''Kinetic modeling of metabolic pathways: Application to serine biosynthesis''. In: Systems Metabolic Engineering, Humana Press. pp. 113–121</ref> | ||
− | <center><math> \frac{ serA*KcatA*\frac{[3PG]}{ | + | <center><math> \frac{ serA*KcatA*\frac{[3PG]}{KA_{3PG}}}{\frac{1 + \frac{[3PG]}{KA_{3PG}} + \frac{[PHP]}{KA_{PHP}} }{1+ \frac{[SER]}{KiA_{SER}}}} </math></center> |
==Parameters== | ==Parameters== |
Revision as of 15:57, 21 March 2014
The enzyme Phosphoglycerate dehydrogenase (PDH) catalyzes the reaction to convert 3-phospho-D-glycerate (P3G) to phosphonooxypyruvate (PHP). The cofactors NADH and NAD+.
Chemical equation
Rate equation
Modified rate equation is used [1]
Parameters
Parameter | Value | Units | Organism | Remarks |
---|---|---|---|---|
1.15 [2] | mM | Escherichia coli | ||
0.55 [3] | 1/s | |||
1.2[3] | mM | |||
0.0032[3] | mM | |||
0.0038[3] | mM |
References
- ↑ Smallbone K, Stanford NJ (2013). Kinetic modeling of metabolic pathways: Application to serine biosynthesis. In: Systems Metabolic Engineering, Humana Press. pp. 113–121
- ↑ Turnaev II, Ibragimova SS, Usuda Y et al (2006). Mathematical modeling of serine and glycine synthesis regulation in Escherichia coli. Proceedings of the fifth international conference on bioinformatics of genome regulation and structure 2:78–83
- ↑ 3.0 3.1 3.2 3.3 Zhao G, Winkler ME (1996). A novel alphaketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. J Bacteriol 178:232–239