Difference between revisions of "Monocarboxylate (Lactate) transporter"
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Revision as of 10:35, 5 March 2014
Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.
Chemical equation
Rate equation
Reversible Michaelis-Menten rate law is used
![\frac{V_{f}\frac{[Lactate_{in}]}{Km_{Lactate_{in}}}- V_{r}\frac{[Lactate_{out}]}{Km_{Lactate_{out}}}}{1+ \frac{[Lactate_{in}]}{Km_{Lactate_{in}}} + \frac{[Lactate_{out}]}{Km_{Lactate_{out}}} }](/wiki/images/math/5/9/d/59d3468d02be251532c898a93215b6a9.png)
Parameter values
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
2.5 [2] | ||
|
|||
|
4.5 | ||
|
References
- ↑ Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)
- ↑ Manning Fox JE et. al. (2000). Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol 529(Pt2):285-293
