Difference between revisions of "Monocarboxylate (Lactate) transporter"

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Revision as of 18:43, 4 March 2014

Monocarboxylate transporters,[1] or MCTs, constitute a family of proton-linked plasma membrane transporters that carry molecules having one carboxylate group (monocarboxylates), such as lactate and pyruvate.

Chemical equation

Lactate_{in} \rightleftharpoons Lactate_{out}

Rate equation

Reversible Michaelis-Menten rate law is used

\frac{V_{f}\frac{[Lactate_{in}]}{Km_{Lactate_{in}}}- V_{r}\frac{[Lactate_{out}]}{Km_{Lactate_{out}}}}{1+ \frac{[Lactate_{in}]}{Km_{Lactate_{in}}} + \frac{[Lactate_{out}]}{Km_{Lactate_{out}}} }

Parameter values

Parameter Value Organism Remarks
V_{mf} 0.0344 HeLa cell line
Vm_{r} 0.013
Km_{LAC} 14.8
Km_{LACout} 4.54


References

  1. ↑ Halestrap AP, Meredith D (2004). The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch. 447 (5): 619–28 (doi)
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