Difference between revisions of "Triosephosphate isomerase"
| Line 19: | Line 19: | ||
|5 <<ref name="Hernandez2011"> Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). ''Modeling cancer glycolysis''. Biochim Biophys Acta, 1807:755–767 ([http://dx.doi.org/10.1016/j.bbabio.2010.11.006 doi]) </ref> | |5 <<ref name="Hernandez2011"> Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). ''Modeling cancer glycolysis''. Biochim Biophys Acta, 1807:755–767 ([http://dx.doi.org/10.1016/j.bbabio.2010.11.006 doi]) </ref> | ||
|Hela cell line | |Hela cell line | ||
| − | |rowspan=" | + | |rowspan="4"| |
|- | |- | ||
|<math>V_{mr}</math> | |<math>V_{mr}</math> | ||
Revision as of 15:48, 4 March 2014
This enzyme rapidly inter-converts the molecules Dihydroxyacetone phosphate (DHAP) and Glyceraldehyde 3-phosphate (Gly3P). Gly3P is removed as soon as it is formed to be used in the next step of glycolysis.
Contents
Chemical equation
Rate equation
Reversible Michaelis-Menten is used [1]
![v = \frac{ V_{mf}\frac{[DHAP]}{K_{DHAP}} - V_{mr}\frac{[Gly3P]}{K_{Gly3P}} }{1 + \frac{[DHAP]}{K_{DHAP}} + \frac{[Gly3P]}{K_{Gly3P}} }](/wiki/images/math/c/4/3/c43ea2245f63ddca8689602949bdf9f4.png)
Paramters
| Parameter | Value | Organism | Remarks |
|---|---|---|---|
|
5 <[1] | Hela cell line | |
|
42[2] | Hela cell line | |
|
0.51[1] | Hela cell line | |
|
1.6[1] | Hela cell line |
Alternative parameter values
References
- ↑ 1.0 1.1 1.2 1.3 Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi) Cite error: Invalid
<ref>tag; name "Hernandez2011" defined multiple times with different content - ↑ Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)
