Difference between revisions of "Enzyme Parameters"
Line 1: | Line 1: | ||
[[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]] | [[Welcome to the In-Silico Model of Cutaneous Lipids Wiki | Return to overview]] | ||
+ | |||
+ | == Data == | ||
Table of enzyme parameters with their respective confidence interval, location and scale parameter. The value for each enzyme parameter is the weighted mode, calculated using literature parameters and the parameter alogirthm described by Breitling, Hawari and Tsigkinopoulou. The algorithm was also used in order to calculate the confidence interval for each data set, the larger the confidence interval, the larger the descrepancy between literature values. The location and scale parameters stated for each parameter describe the log normal distributions which were generated using a two-by-two system of the equations containing the cumulative distribution function (CDF) and the mode. For more details about these calculations please visit [http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php/Quantification_of_parameter_uncertainty Quantification of parameter uncertainty]. | Table of enzyme parameters with their respective confidence interval, location and scale parameter. The value for each enzyme parameter is the weighted mode, calculated using literature parameters and the parameter alogirthm described by Breitling, Hawari and Tsigkinopoulou. The algorithm was also used in order to calculate the confidence interval for each data set, the larger the confidence interval, the larger the descrepancy between literature values. The location and scale parameters stated for each parameter describe the log normal distributions which were generated using a two-by-two system of the equations containing the cumulative distribution function (CDF) and the mode. For more details about these calculations please visit [http://www.systemsbiology.ls.manchester.ac.uk/wiki/index.php/Quantification_of_parameter_uncertainty Quantification of parameter uncertainty]. | ||
Line 187: | Line 189: | ||
|} | |} | ||
+ | == Distributions == | ||
+ | [[File:EnzymeKcatDistrbutions.jpg|center|500px]] | ||
== Related Pages == | == Related Pages == |
Revision as of 13:27, 14 June 2016
Data
Table of enzyme parameters with their respective confidence interval, location and scale parameter. The value for each enzyme parameter is the weighted mode, calculated using literature parameters and the parameter alogirthm described by Breitling, Hawari and Tsigkinopoulou. The algorithm was also used in order to calculate the confidence interval for each data set, the larger the confidence interval, the larger the descrepancy between literature values. The location and scale parameters stated for each parameter describe the log normal distributions which were generated using a two-by-two system of the equations containing the cumulative distribution function (CDF) and the mode. For more details about these calculations please visit Quantification of parameter uncertainty.
Quantifying Parameter Uncertainty | |||||
---|---|---|---|---|---|
Enzyme | Parameter | Weighted
Mode |
Confidence
Interval |
Location
Parameter |
Scale
Parameter |
12-LOX | Km | 0.00755 | 5.83 | -4.36 | 0.727 |
Kcat | 252 | 1.38 | 5.56 | 0.159 | |
15-LOX | Km | 0.00780 | 1.78 | -4.78 | 0.278 |
Kcat | 66.6 | 5.30 | 4.68 | 0.700 | |
5-LOX | Km | 0.00855 | 4.19 | -4.38 | 0.617 |
Kcat | 1460 | 1.50 | 7.29 | 0.0244 | |
COX-2 | Km | 0.00368 | 3.38 | -5.32 | 0.540 |
Kcat | 1640 | 1.50 | 7.44 | 0.199 | |
cPLA2 | Km | 0.0113 | 4.21 | -4.11 | 0.618 |
Kcat | 2650 | 2.63 | 8.08 | 0.443 | |
LTA4H | Km | 0.00230 | 5.28 | -5.59 | 0.695 |
Kcat | 20.4 | 3.87 | 3.36 | 0.589 | |
LTC4S | Km | 0.03 | 6.75 | -2.91 | 0.773 |
Kcat | 1440 | 1.50 | 7.29 | 0.145 | |
PGDS | Km | 0.0040 | 10.0 | -4.78 | 0.891 |
Kcat | 158 | 10.0 | 5.86 | 0.891 | |
PGES | Km | 0.162 | 1.50 | -1.81 | 0.0825 |
Kcat | 2820 | 1.50 | 7.95 | 0.0610 | |
PGFS | Km | 0.00340 | 6.90 | -5.08 | 0.780 |
Kcat | 14.9 | 10.0 | 3.50 | 0.891 | |
PGIS | Km | 0.0126 | 1.50 | -4.36 | 0.123 |
Kcat | 125 | 1.50 | 4.85 | 0.159 | |
PHGPx | Km | 5.56 | 19.3 | 2.86 | 1.07 |
Kcat | 1280 | 6.31 | 10.0 | 0.752 | |
TXAS | Km | 0.00700 | 2.45 | -4.79 | 0.415 |
Kcat | 1630 | 1.50 | 7.40 | 0.0740 |