Difference between revisions of "Hexokinase"
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|<math>Km_{ADP}</math> | |<math>Km_{ADP}</math> |
Revision as of 12:33, 4 March 2014
The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from Adenosine triphosphate (ATP) is transferred to glucose producing glucose 6-phosphate (Glc6P).
Contents
Chemical equation
Rate equation
Without inhibition
Random Bi-Bi Michaelis Menten is used.[1]
With allosteric inhibition
Parameters
Without inhibition
Parameter | Value | Organism | Remarks |
---|---|---|---|
0.06 [2] | HeLa cell line | ||
651[3] | |||
0.1[1] | |||
1.1[1] | |||
[1] | |||
3.5[1] |
With inhibition
Parameter | Value | Organism | Remarks |
---|---|---|---|
0.06 [2] | HeLa cell line | ||
0.1[1] | |||
1.1[1] | |||
[4] |
Alternative parameter values
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)
- ↑ 2.0 2.1 Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi) Cite error: Invalid
<ref>
tag; name "Hernandez_2006" defined multiple times with different content - ↑ Arbitrary value
- ↑ Wilson J E (2003). Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. Journal of Experimental Biology, 206, pp. 2049–2057 (doi)