Difference between revisions of "Hexokinase"
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The [http://en.wikipedia.org/wiki/Enzyme enzyme] hexokinase phosphorylates (adds a [http://en.wikipedia.org/wiki/Phosphate phosphate] group to) [http://en.wikipedia.org/wiki/Glucose glucose] in the cell's [http://en.wikipedia.org/wiki/Cytoplasm cytoplasm]. In the process, a phosphate group from [http://en.wikipedia.org/wiki/Adenosine_triphosphate Adenosine triphosphate (ATP)] is transferred to glucose producing [http://en.wikipedia.org/wiki/Glucose_6-phosphate glucose 6-phosphate (Glc6P)]. | The [http://en.wikipedia.org/wiki/Enzyme enzyme] hexokinase phosphorylates (adds a [http://en.wikipedia.org/wiki/Phosphate phosphate] group to) [http://en.wikipedia.org/wiki/Glucose glucose] in the cell's [http://en.wikipedia.org/wiki/Cytoplasm cytoplasm]. In the process, a phosphate group from [http://en.wikipedia.org/wiki/Adenosine_triphosphate Adenosine triphosphate (ATP)] is transferred to glucose producing [http://en.wikipedia.org/wiki/Glucose_6-phosphate glucose 6-phosphate (Glc6P)]. | ||
− | + | =Chemical equation= | |
<center><math>Glucose_{in} + ATP \rightleftharpoons Glc6P + ADP</math></center> | <center><math>Glucose_{in} + ATP \rightleftharpoons Glc6P + ADP</math></center> | ||
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== Rate equation == | == Rate equation == | ||
− | ===Without | + | ===Without inhibition=== |
Random Bi-Bi Michaelis Menten is used.<ref name="Hernandez2011"> Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 ([http://dx.doi.org/10.1016/j.bbabio.2010.11.006 doi]) </ref> | Random Bi-Bi Michaelis Menten is used.<ref name="Hernandez2011"> Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 ([http://dx.doi.org/10.1016/j.bbabio.2010.11.006 doi]) </ref> | ||
Revision as of 11:18, 4 March 2014
The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from Adenosine triphosphate (ATP) is transferred to glucose producing glucose 6-phosphate (Glc6P).
Contents
Chemical equation
Rate equation
Without inhibition
Random Bi-Bi Michaelis Menten is used.[1]
Allosteric inhibition
Parameters
Parameter | Value | Organism | Remarks |
---|---|---|---|
0.46 [2] | HeLa cell line | Vm in U × (mg total cellular protein) at C | |
1[3] | |||
9.3 | |||
10[3] |
Alternative parameter values
References
- ↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)
- ↑ Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)
- ↑ 3.0 3.1 Arbitrary value