Difference between revisions of "Hexokinase"
Line 18: | Line 18: | ||
|- | |- | ||
|<math>V_{mf}</math> | |<math>V_{mf}</math> | ||
− | |0.46 <ref name=" | + | |0.46 <ref name="Hernandez_2006"> Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, ''et al.'' (2006). ''Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase''. FEBS J., 273 , pp. 1975–1988([http://dx.doi.org/doi:10.1111/j.1742-4658.2006.05214.x doi]) </ref> |
|rowspan="4"|HeLa cell line | |rowspan="4"|HeLa cell line | ||
|rowspan="4"|Vm in U × (mg total cellular protein) at <math>37^{\circ}</math>C | |rowspan="4"|Vm in U × (mg total cellular protein) at <math>37^{\circ}</math>C | ||
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|<math>K_{Glucose_{in}}</math> | |<math>K_{Glucose_{in}}</math> | ||
− | |9.3 | + | |9.3 |
|- | |- | ||
|<math>K_{Glucose_{out}}</math> | |<math>K_{Glucose_{out}}</math> |
Revision as of 14:02, 3 March 2014
The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from Adenosine triphosphate (ATP) is transferred to glucose producing glucose 6-phosphate (Glc6P).
Contents
Chemical equation
Rate equation
Random Bi-Bi Michaelis Menten is used.[1]
Parameters
Parameter | Value | Organism | Remarks |
---|---|---|---|
0.46 [2] | HeLa cell line | Vm in U × (mg total cellular protein) at C | |
1[3] | |||
9.3 | |||
10[3] |
Alternative parameter values
References
- ↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)
- ↑ Marín-Hernández A , Rodríguez-Enríquez S, Vital-González P A, et al. (2006). Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase. FEBS J., 273 , pp. 1975–1988(doi)
- ↑ 3.0 3.1 Arbitrary value