Difference between revisions of "Glucose Transporter"

Revision as of 13:16, 3 March 2014

Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Glucose is a vital source of energy for all life.

Glucose_{out} \rightleftharpoons Glucose_{in}

Mono-Substrate reversible Michaelis-Menten with Haldane substitution is used^[1].

v = \frac{V_{mf}\Big([Glucose_{out}] - \frac{[Glucose_{in}]}{K_{eq}}\Big)}{K_{Glucose_{out}}\Big(1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}}\Big) + [Glucose_{out}}]

Parameter	Value	Organism	Remarks
$V_{mf}$	0.017 ^[2]	HeLa cell line	Vm in U × (mg total cellular protein) at $37^{\circ}$ C
$K_{eq}$	1^[3]
$K_{Glucose_{in}}$	9.3^[2]
$K_{Glucose_{out}}$	10^[3]
Total		15.00

↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
↑ ^2.0 ^2.1 Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, et. al.(2009). Kinetics of transport and phosphorylation of glucose in cancer cells. Journal of Cell. Physiology, 221 , pp. 552–559 (doi)
↑ ^3.0 ^3.1 Arbitrary value

@@ Line 18: / Line 18: @@
 |<math>V_{mf}</math>
 |0.017 <ref name="Ror_2009"> Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, ''et. al.''(2009). ''Kinetics of transport and phosphorylation of glucose in cancer cells''. Journal of Cell. Physiology, 221 , pp. 552–559 ([http://dx.doi.org/doi:10.1002/jcp.21885 doi]) </ref>
-|HeLa cell line
+|rowspan="4"|HeLa cell line
 |Vm in U × (mg total cellular protein) at <math>37^{\circ}</math>C
 |-