Difference between revisions of "Glucose Transporter"

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|0.055 <ref name="> Marín-Hernández A, Rodríguez-Enríquez S, Vital-González P A ''et al.'' (2006). ''Determining and understanding the control of glycolysis in fast-growth tumor cells. Flux control by an over-expressed but strongly product-inhibited hexokinase''. FEBS J, Vol. 273 , pp. 1975–1988 ([http://dx.doi.org/doi:10.1111/j.1742-4658.2006.05214.x doi]) </ref>
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|0.055 <ref name="Ror_2009"> Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, ''et. al.''(2009). ''Kinetics of transport and phosphorylation of glucose in cancer cells''. J. Cell. Physiology, 221 , pp. 552–559 ([http://dx.doi.org/doi:10.1002/jcp.21885 doi]) </ref>
 
|Human Tumor Cell
 
|Human Tumor Cell
 
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Revision as of 12:57, 3 March 2014

Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose over a plasma membrane. Glucose is a vital source of energy for all life.

Chemical equation

Glucose_{out} \rightleftharpoons Glucose_{in}

Rate equation

Mono-Substrate reversible Michaelis-Menten with Haldane substitution is used[1].

v = \frac{V_{mf}\Big([Glucose_{out}] - \frac{[Glucose_{in}]}{K_{eq}}\Big)}{K_{Glucose_{out}}\Big(1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}}\Big) + [Glucose_{out}}]

Parameters

Parameter Value Organism Remark
V_{mf} 0.055 [2] Human Tumor Cell
Bread 4 3.00
Butter 1 5.00
Total 15.00

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011). Modeling cancer glycolysis. Biochim Biophys Acta, 1807:755–767 (doi)
  2. Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez J C, et. al.(2009). Kinetics of transport and phosphorylation of glucose in cancer cells. J. Cell. Physiology, 221 , pp. 552–559 (doi)