Difference between revisions of "Hexose-6-phosphate isomerase"

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The enzyme Hexose-6-phosphate isomerase converts glucose 6-phosphate into its isomer fructose 6-phosphate. Isomers have the same molecular formula, but the atoms of each molecule are arranged differently.
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The enzyme Hexose-6-phosphate isomerase converts [http://en.wikipedia.org/wiki/Glucose-6-phosphate Glucose 6-phosphate (Glc6P) into its isomer [http://en.wikipedia.org/wiki/Fructose_6-phosphate Fructose 6-phosphate (Fru6P)]. [http://en.wikipedia.org/wiki/Isomers Isomers] have the same molecular formula, but the atoms of each molecule are arranged differently.
  
 
== Chemical reaction ==
 
== Chemical reaction ==

Revision as of 10:14, 28 February 2014

The enzyme Hexose-6-phosphate isomerase converts Glucose 6-phosphate (Glc6P) into its isomer [http://en.wikipedia.org/wiki/Fructose_6-phosphate Fructose 6-phosphate (Fru6P). Isomers have the same molecular formula, but the atoms of each molecule are arranged differently.

Chemical reaction

Glc6P \rightleftharpoons Fru6P

Rate equation

Reversible competitive inhibition with Ery4P, 6PG and FBP. [1]

\frac{V_{mf}\frac{[Glc6P]}{K_{Glc6P}} - V_{mr} \frac{[Fru6P]}{K_{Fru6P}} }{ 1 + \frac{[Glc6P]}{K_{Glc6P}} + \frac{[Fru6P]}{K_{Fru6P}} + \frac{[ERY4P]}{K_{ERY4P}} + \frac{[6PG]}{K_{6PG}} + \frac{[FBP]}{K_{FBP}} }

Parameters

Alternative parameter values

Refences

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)