Difference between revisions of "Hexokinase"

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The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from ATP is transferred to glucose producing glucose 6-phosphate.
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The [http://en.wikipedia.org/wiki/Enzyme enzyme] hexokinase phosphorylates (adds a [http://en.wikipedia.org/wiki/Phosphate phosphate] group to) [http://en.wikipedia.org/wiki/Glucose glucose] in the cell's [http://en.wikipedia.org/wiki/Cytoplasm cytoplasm]. In the process, a phosphate group from [http://en.wikipedia.org/wiki/Adenosine_triphosphate ATP] is transferred to glucose producing [http://en.wikipedia.org/wiki/Glucose_6-phosphate glucose 6-phosphate].
  
 
== Chemical equation ==
 
== Chemical equation ==

Revision as of 10:03, 28 February 2014

The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from ATP is transferred to glucose producing glucose 6-phosphate.

Chemical equation

Glucose_{in} + ATP \rightleftharpoons Glc6P + ADP

Rate equation

Random Bi-Bi Michaelis Menten is used.[1]

 v = \frac{\frac{V_{mf}}{K_{Glucose_{in}}K_{ATP}}\Big( [Glucose_{in}][ATP] - \frac{[Glc6P][ADP]}{K_{eq}} \Big)}{1 + \frac{[Glucose_{in}]}{K_{Glucose_{in}}} + \frac{[ATP]}{K_{ATP}} + \frac{[Glucose_{in}][ATP]}{K_{Glucose_{in}}K_{ATP}} + \frac{[Glc6P]}{K_{Glc6P}} + \frac{[ADP]}{K_{ADP}} +\frac{[Glc6P][ADP]}{K_{Glc6P}K_{ADP}} + \frac{[Glucose_{in}][ADP]}{K_{Glucose_{in}}K_{ADP}} +\frac{[Glc6P][ATP]}{K_{Glc6P}K_{ATP}} }

Parameters

Alternative parameter values

References

  1. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)