3-phosphoglycerate kinase

Phosphoglycerate kinase (PGK) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP. Like all kinases it is a transferase.

Chemical equation

$1,3BPG + ADP \rightleftharpoons 3PG + ATP$

Rate equation

Random Bi-Bi reversible Michaelis-Menten euation for non-interacting substrates are used .

$\frac{V_{mf}\frac{[1,3BPG][ADP]}{K_{1,3BPG} K_{ADP}} - V_{mr}\frac{[3PG][ATP]}{K_{3PG} K_{ATP}}}{1 + \frac{[1,3BPG]}{K_{1,3BPG}} + \frac{[ADP]}{K_{ADP}} + \frac{[1,3BPG][ADP]}{K_{1,3BPG} K_{ADP}} + \frac{[3PG][ATP]}{K_{3PG} K_{ATP}} + \frac{[3PG]}{K_{3PG}} + \frac{[ADP]}{K_{ADP}} }$

Alternative parameter values

Vrizlynn L.L. Thing, Tong-Wei Chua, Ming-Lee Cheong - Modeling cancer glycolysis

Biochimica et Biophysica Acta (BBA) - Bioenergetics 1807(6):755 - 767, Los Alamitos, CA, USA, 11 2011

Bibtex

Author : Vrizlynn L.L. Thing, Tong-Wei Chua, Ming-Lee Cheong
Title : Modeling cancer glycolysis
In : Biochimica et Biophysica Acta (BBA) - Bioenergetics -
Address : Los Alamitos, CA, USA
Date : 11 2011