Difference between revisions of "Mitocondrial pyruvate metabolism"
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<center><math> v=K_1A-K_2B</math></center><br> | <center><math> v=K_1A-K_2B</math></center><br> | ||
<center><math> v=k_1A \left(1-\frac{K_2B}{K_1A} \right)</math></center><br> | <center><math> v=k_1A \left(1-\frac{K_2B}{K_1A} \right)</math></center><br> | ||
+ | Considering <math>K_{eq} = \frac{K_1}{K_2}</math> and <math>\tau = \frac{P_1P_2 \ldots}{S_1S_2 \ldots}</math> we have, | ||
<center><math> v=k_1A \left(1-\frac{\tau}{K_{eq}} \right)</math></center><br> | <center><math> v=k_1A \left(1-\frac{\tau}{K_{eq}} \right)</math></center><br> | ||
Revision as of 10:32, 12 May 2014
Mitocondrial pyruvate metabolism(MPM) is an enzyme that generates ATP form pyruvate.
Chemical reaction
Rate equation
- Chemical reactions proceed to equilibrium within closed systems. For a simple reaction it is defined as where forward and reverse rates are equal.
- Equilibrium is not reached in open system due to influx and outflux. Mass action ratio[1] for reaction is defined as where subscript ob represents observable at a given point.
- Deviation from equilibrium is measured with Disequilibrium constant as
- Given the simple uni molecular reaction the mass action equation can be modified as
Considering and we have,
Constant flux is used where is considered.
Parameter values
Parameter | Value | Organism | Remarks |
---|---|---|---|
[2] | HeLa cell line | Constant flux |
References
- ↑ Hess B. and Brand K. (1965), Enzymes and metabolite profiles. In Control of energy metabolism. III. Ed. B. Chance, R. K. Estabrook and J. R. Williamson. New York: Academic Press
- ↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)