Difference between revisions of "Mitocondrial pyruvate metabolism"
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*Deviation from equilibrium is measured with '''Disequilibrium constant <math>\rho</math>''' as <math>\rho = \frac{\tau}{K_{eq}}</math> | *Deviation from equilibrium is measured with '''Disequilibrium constant <math>\rho</math>''' as <math>\rho = \frac{\tau}{K_{eq}}</math> | ||
*Given the simple uni molecular reaction <math>A \leftrightarrow B</math> the mass action equation can be modified as | *Given the simple uni molecular reaction <math>A \leftrightarrow B</math> the mass action equation can be modified as | ||
− | <center><math> v=k_1A- | + | <center><math> v=K_1A-K_2B</math></center> |
+ | <center><math> v=k_1A \left(1-\frac{K_2B}{K_1A} \right)</math></center> | ||
Constant flux is used where <math> v = 1 \times 10^{-4}</math> is considered. | Constant flux is used where <math> v = 1 \times 10^{-4}</math> is considered. |
Revision as of 10:28, 12 May 2014
Mitocondrial pyruvate metabolism(MPM) is an enzyme that generates ATP form pyruvate.
Chemical reaction
Rate equation
- Chemical reactions proceed to equilibrium within closed systems. For a simple reaction it is defined as where forward and reverse rates are equal.
- Equilibrium is not reached in open system due to influx and outflux. Mass action ratio[1] for reaction is defined as where subscript ob represents observable at a given point.
- Deviation from equilibrium is measured with Disequilibrium constant as
- Given the simple uni molecular reaction the mass action equation can be modified as
Constant flux is used where is considered.
Parameter values
Parameter | Value | Organism | Remarks |
---|---|---|---|
[2] | HeLa cell line | Constant flux |
References
- ↑ Hess B. and Brand K. (1965), Enzymes and metabolite profiles. In Control of energy metabolism. III. Ed. B. Chance, R. K. Estabrook and J. R. Williamson. New York: Academic Press
- ↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)