Difference between revisions of "Mitocondrial pyruvate metabolism"

Revision as of 10:20, 12 May 2014

Mitocondrial pyruvate metabolism(MPM) is an enzyme that generates ATP form pyruvate.

Pyruvate + 13ADP + 13Pi \rightarrow 13ATP

Chemical reactions proceed to equilibrium within closed systems. For a simple reaction $A \rightarrow B$ it is defined as $K_{eq} = \frac{[B]_{eq}}{[A]_{eq}}$ where forward and reverse rates are equal.
Equilibrium is not reached in open system due to influx and outflux. Mass action ratio $\tau$ for $A \rightarrow B$ reaction is defined as $\tau = \frac{[B]_{ob}}{[A]_{ob}}$ where subscript ob represents observable at a given point.
Deviation from equilibrium is measured with disequilibrium constant $\rho$ as $\rho = \frac{\tau}{K_{eq}}$

Constant flux is used where $v = 1 \times 10^{-4}$ is considered.

Parameter	Value	Organism	Remarks
$V$	$1 \times 10^{-4}$ ^[1]	HeLa cell line	Constant flux

↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)

@@ Line 9: / Line 9: @@
 *Chemical reactions proceed to equilibrium within closed systems. For a simple reaction <math>A \rightarrow B</math> it is defined as <math>K_{eq} = \frac{[B]_{eq}}{[A]_{eq}}</math> where forward and reverse rates are equal.
 *Equilibrium is not reached in open system due to influx and outflux. '''Mass action ratio''' <math>\tau</math> for <math>A \rightarrow B</math> reaction is defined as <math>\tau = \frac{[B]_{ob}}{[A]_{ob}}</math> where subscript ''ob'' represents observable at a given point.
-*Deviation from equilibrium is measured with '''disequilibrium constant <math>\rho</math>''' as <math>\rho = \frac{Mass action ratio (\tao)}{K_{eq}}</math>
+*Deviation from equilibrium is measured with '''disequilibrium constant <math>\rho</math>''' as <math>\rho = \frac{\tau}{K_{eq}}</math>
 Constant flux is used where <math> v = 1 \times 10^{-4}</math> is considered.