Difference between revisions of "Mitocondrial pyruvate metabolism"

Revision as of 10:17, 12 May 2014

Mitocondrial pyruvate metabolism(MPM) is an enzyme that generates ATP form pyruvate.

Pyruvate + 13ADP + 13Pi \rightarrow 13ATP

Chemical reactions proceed to equilibrium within closed systems. For a simple reaction $A \rightarrow B$ it is defined as $K_{eq} = \frac{[B]_{eq}}{[A]_{eq}}$ where forward and reverse rates are equal.
Equilibrium is not reached in open system due to influx and outflux. Mass action ratio Failed to parse (Cannot store math image on filesystem.): \Tau for $A \rightarrow B$ reaction is defined as $\tau = \frac{[B]_{ob}}{[A]_{ob}}$ where subscript ob represents observable at a given point.

Constant flux is used where $v = 1 \times 10^{-4}$ is considered.

Parameter	Value	Organism	Remarks
$V$	$1 \times 10^{-4}$ ^[1]	HeLa cell line	Constant flux

↑ Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S et al (2011) Modeling cancer glycolysis. Biochim Biophys Acta 1807:755–767 (doi)

@@ Line 8: / Line 8: @@
 ==Rate equation==
 *Chemical reactions proceed to equilibrium within closed systems. For a simple reaction <math>A \rightarrow B</math> it is defined as <math>K_{eq} = \frac{[B]_{eq}}{[A]_{eq}}</math> where forward and reverse rates are equal.
-*Equilibrium is not reached in open system due to influx and outflux. '''Mass action ratio''' <math>\tau</math> for <math>A \rightarrow B</math> reaction is defined as <math>\tau = \frac{[B]_{ob}}{[A]_{ob}}</math> where subscript ''ob'' represents observable at a given point.
+*Equilibrium is not reached in open system due to influx and outflux. '''Mass action ratio''' <math>\Tau</math> for <math>A \rightarrow B</math> reaction is defined as <math>\tau = \frac{[B]_{ob}}{[A]_{ob}}</math> where subscript ''ob'' represents observable at a given point.
 Constant flux is used where <math> v = 1 \times 10^{-4}</math> is considered.